O-2545

From Wikipedia, the free encyclopedia

O-2545
Systematic (IUPAC) name

(6aR,10aR)-6a,7,10,10a-Tetrahydro-3-[5-(1H-imidazol-1-yl)-1,1-dimethylpentyl]-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol
Identifiers
CAS number	874745-42-3
ATC code	?
PubChem	?
Chemical data
Formula	C₂₆H₃₆N₂O₂
Mol. mass	408.575 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule I (US)
Routes	?

O-2545 is a drug which is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB₁ and CB₂ receptors, with Ki values of 1.5nM at CB₁ and 0.32nM at CB₂.^[1]

This article about a cannabinoid is a stub. You can help Wikipedia by expanding it.

References

^ Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water-soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics. 2006 Sep;318(3):1230-9. PMID 16757541

Cannabinoids

Plant cannabinoids

CBCV • CBD • CBDV • CBGM • CBGV • CBN • CBG • CBV • CBL • THC • THC-C4 • THCV

Cannabinoid metabolites

8,11-DiOH-THC • 11-COOH-THC • 11-OH-THC

Endogenous cannabinoids

Arachidonoyl ethanolamide (Anandamide or AEA) • 2-Arachidonoylglycerol (2-AG) • 2-Arachidonyl glyceryl ether (noladin ether) • Virodhamine • Palmitoylethanolamide (PEA) • N-Arachidonoyl dopamine (NADA) • Oleamide

Synthetic cannabinoid
receptor agonists

Classical cannabinoids (Dibenzopyrans)	A-40174 •A-41988 • A-42574 •Ajulemic acid • AM-087 • AM-411 • AM-855 • AM-905 • AM-906 • AM-919 • AM-938 • AM-4030 • AMG-1 • AMG-3 • AMG-36 • AMG-41 • Dexanabinol (HU-211) • DMHP • Dronabinol • HHC •HU-210 •HU-243 •JWH-051 • JWH-133 • JWH-139 •JWH-229 •JWH-359 • L-759,633 • L-759,656 • Levonantradol (CP 50,5561) • Nabazenil •Nabidrox (Canbisol) •Nabilone • Nabitan • Naboctate •O-806 • O-823 • O-1057 • O-1125 • O-1238 • O-2545 • O-2694 • Parahexyl • Perrottetinene •Pirnabine •THC-O-acetate • THC-O-phosphate
Nonclassical cannabinoids	CP 47,497 • CP 55,244 • CP 55,940 •HU-308 •Nonabine •SPA-229 •Tinabinol •2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
Aminoalkylindoles	AM-630 • AM-694 •AM-1241 • JWH-007 •JWH-015 • JWH-018 • JWH-073 • JWH-081 • JWH-122 •JWH-167 •JWH-200 • JWH-203 •JWH-210 •JWH-249 •JWH-250 •JWH-398 •GW-405,833 (L-768,242) •Pravadoline • WIN 55,212-2
Aminoalkylpyrroles	JWH-030 • JWH-147 • JWH-307
Eicosanoids	AM-883 • Arachidonyl-2'-chloroethylamide • Arachidonylcyclopropylamide • Methanandamide • O-585 • O-689 • O-1812 •O-1860 • O-1861
Others	Abnormal cannabidiol • BAY 38-7271 • BAY 59-3074 • CB-13 •GW-842,166X •JWH-171 •O-1918 •O-2220 •Leelamine •Org 28611 •VSN-16

Endocannabinoid
activity enhancers

AM-404 • CAY-10401 •CAY-10402 •JZL184 •N-arachidonoyl-serotonin •O-1624 • PF-622 •PF-750 •PF-3845 •URB-597 • URB-602 •Genistein •Arvanil •Olvanil •Kaempferol •Biochanin A •URB-754

Cannabinoid receptor
antagonists and
inverse agonists

AM-251 • AM-281 • AM-630 • BML-190 •CAY-10508 •CB-25 • CB-52 •Drinabant •Ibipinabant •JTE-907 • LY-320,135 •MK-9470 •NESS-0327 • O-1184 • O-1248 •O-2050 • O-2654 • Org 27569 •Otenabant •Rimonabant • SR-144,528 • Surinabant • Taranabant •VCHSR

alemão (de)	búlgaro (bg)	chinês (zh)	croata (hr)
dinamarquês (da)	eslovaco (sk)	esloveno (sl)	espanhol (es)
estoniano (et)	farsi (fa)	finlandês (fi)	francês (fr)
grego (el)	hebraico (he)	hindi (hi)	holandês (nl)
húngaro (hu)	indonésio (id)	inglês (en)	islandês (is)
italiano (it)	japonês (ja)	korean (ko)	letão (lv)
língua árabe (ar)	lituano (lt)	norueguês (no)	polonês (pl)
português (pt)	romeno (ro)	russo (ru)	sérvio (sr)
sueco (sv)	tailandês (th)	tcheco (cs)	turco (tr)
vietnamês (vi)

alemão (de)	búlgaro (bg)	chinês (zh)	croata (hr)
dinamarquês (da)	eslovaco (sk)	esloveno (sl)	espanhol (es)
estoniano (et)	farsi (fa)	finlandês (fi)	francês (fr)
grego (el)	hebraico (he)	hindi (hi)	holandês (nl)
húngaro (hu)	indonésio (id)	inglês (en)	islandês (is)
italiano (it)	japonês (ja)	korean (ko)	letão (lv)
língua árabe (ar)	lituano (lt)	norueguês (no)	polonês (pl)
português (pt)	romeno (ro)	russo (ru)	sérvio (sr)
sueco (sv)	tailandês (th)	tcheco (cs)	turco (tr)
vietnamês (vi)